منابع مشابه
Secondary myeloid neoplasias: an emerging group of diseases
DOI: 10.5581/1516-8484.20110111 Centro de Investigación del Cáncer – IBMCC, Universidad de Salamanca, Consejo Superior de Investigaciones Científicas – CSIC and Hematology Service, Hospital Universitario de Salamanca, Spain Jesús M Hernández-Rivas Secondary myeloid neoplasias are a heterogeneous group of diseases characterized by the proliferation of myeloid cells; they were recently recognized...
متن کاملMonosomal karyotype in myeloid neoplasias: a literature review
In 2008, the concept of the monosomal karyotype (MK) in adult acute myeloid leukemia (AML) patients was introduced, defined by the presence of a chromosomal aberration pattern characterized by the presence of at least two autosomal monosomies or of one monosomy plus one or more structural aberrations (not including loss of a chromosome). We present a systematic review of the literature about th...
متن کاملMyeloid Neoplasias: What Molecular Analyses Are Telling Us
In the last decades, cytogenetic and molecular characterizations of hematological disorders at diagnosis and followup have been most valuable for guiding therapeutic decisions and prognosis. Genetic and epigenetic alterations detected by different procedures have been associated to different cancer types and are considered important indicators for disease classification, differential diagnosis,...
متن کاملGenetic susceptibility to Hodgkin's disease and secondary neoplasias: FISH analysis reveals patients at high risk of developing secondary neoplasia.
BACKGROUND Cytotoxic drugs administered before high-dose therapy (HDT) represent a significant factor in the development of leukemic complications in patients with lymphoid malignancies. This retrospective study was used to detect evidence of abnormal therapy-related myelodysplasia/secondary acute myeloid leukaemia (tMDS/sAML) clones before HDT in a subset of patients who subsequently developed...
متن کاملClonal architecture of secondary acute myeloid leukemia.
BACKGROUND The myelodysplastic syndromes are a group of hematologic disorders that often evolve into secondary acute myeloid leukemia (AML). The genetic changes that underlie progression from the myelodysplastic syndromes to secondary AML are not well understood. METHODS We performed whole-genome sequencing of seven paired samples of skin and bone marrow in seven subjects with secondary AML t...
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ژورنال
عنوان ژورنال: Revista Brasileira de Hematologia e Hemoterapia
سال: 2011
ISSN: 1516-8484
DOI: 10.5581/1516-8484.20110111